Cell death execution mechanisms in Drosophila
نویسندگان
چکیده
Programmed cell death (PCD) plays a crucial role in neural development as well as in neurodegeneration. To dissect the molecular and genetic pathways of neural cell death, we performed genetic studies using the fruit fly, Drosophila. Our reverse genetic studies showed the significant similarities of cell death execution mechanisms between mammals and Drosophila. A comprehensive search for neural cell death genes is underway by using Gal4/UAS-based strategies in Drosophila. M. Miura
منابع مشابه
Genetic control of programmed cell death in Drosophila melanogaster.
Apoptosis is a genetically controlled form of cell death that is an important feature of animal development and homeostasis. The genes involved in the control and execution of apoptosis are conserved throughout evolution. However, the actual molecular mechanisms used by these genes vary from species to species. In this review, we focus on the genetic components of apoptosis in the fruit fly Dro...
متن کاملRab11 is required for maintenance of cell shape via βPS integrin mediated cell adhesion in Drosophila
In eukaryotes, vesicle trafficking is regulated by the small monomeric GTPases of the Rab protein family. Rab11, (a subfamily of the Ypt/Rab gene family) an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment. In an earlier communication, we have shown th...
متن کاملDrosophila IKK-Related Kinase Regulates Nonapoptotic Function of Caspases via Degradation of IAPs
Caspase activation has been extensively studied in the context of apoptosis. However, caspases also control other cellular functions, although the mechanisms regulating caspases in nonapoptotic contexts remain obscure. Drosophila IAP1 (DIAP1) is an endogenous caspase inhibitor that is crucial for regulating cell death during development. Here we describe Drosophila IKK-related kinase (DmIKKvare...
متن کاملDeath by necrosis
Cells suffer necrotic death when exposed to extreme environmental conditions, adverse and excessive stimuli, or when deleterious mutations are encoded in their genetic material. Unlike apoptosis, which involves a highly regulated and elaborate network of biochemical events and cascades, necrosis has been considered generally to be a chaotic decadence process that effects the inexorable demise o...
متن کاملDeath by necrosis. Uncontrollable catastrophe, or is there order behind the chaos?
Cells suffer necrotic death when exposed to extreme environmental conditions, adverse and excessive stimuli, or when deleterious mutations are encoded in their genetic material. Unlike apoptosis, which involves a highly regulated and elaborate network of biochemical events and cascades, necrosis has been considered generally to be a chaotic decadence process that effects the inexorable demise o...
متن کامل